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The routes of hydrogen gas administration in animal models and human clinical studies are roughly classified into three types: inhalation of hydrogen gas, drinking hydrogen dissolved in water and injection of hydrogen dissolved in saline [19]

A Students t -test or MannWhitney U -Test was used to determine significant differences in pharmacokinetic parameters between oral administration of pure panduratin A and fingerroot extract, and between oral administrations of fingerroot extract for 1 day and 7 days

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Another marker widely used to measure oxidized base lesion is 8-oxo-2-deoxyguanosine (8-OHdG), as, among all purine and pyridine bases, guanine is the most prone to oxidation and a common biomarker reflecting the balance between oxidative damage and repair rate [55]